Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression
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چکیده
منابع مشابه
Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex.
Glutamate and its synthetic analogues N-methyl-d-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tig...
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Introduction: Cortical Spreading Depression (CSD) is a propagating wave of neural and glial cell depolarization with important role in several clinical disorders. Repetitive Transcranial Magnetic Stimulation (rTMS) is a potential tool with preventive treatment effects in psychiatric and neuronal disorders. In this paper, we study the effects of rTMS on CSD by using behavioral and histological a...
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Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
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Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
متن کاملRetention of cerebrovascular dilation after cortical spreading depression in anesthetized rabbits.
BACKGROUND AND PURPOSE We examined responses of rabbit pial arterioles to three different stimuli before and after induction of cortical spreading depression. METHODS In urethane-anesthetized rabbits equipped with a closed cranial window, we measured pial arteriolar diameter during baseline conditions, topical application of calcitonin gene-related peptide (CGRP), topical application of acety...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2008
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2008.09.008